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How Does Cialis (Tadalafil) Work?

Updated Jul,2020

Effectively treat erectile dysfunction with Cialis or the generic version Tadalafil. Cialis (Tadalafil) works by relaxing blood vessels and increasing the blood flow to the penis, resulting in an erection. Cialis and Tadalafil prevent an enzyme called phosphodiesterase type-5 from working too quickly, which may be a contributing factor to erectile dysfunction.

Will Cialis (Tadalafil) really work to treat my ED?

When you're aroused, your nerves send chemical signals to the blood vessels in your penis. Blood vessels in the penis open up and allow blood to flow in.

At the same time, veins close. Pressure then traps the blood within the Corpora Cavernosa. This causes the penis to expand and become erect.

With erectile dysfunction, the blood vessels are failing to open up properly. Cialis and Tadalafil work by relaxing the muscles in the blood vessels and increase blood flow to your penis. This causes your penis to become erect.

An enzyme called phosphodiesterase type-5 acts too quickly, causing an erection to become challenging to sustain. Cialis (Tadalafil) helps control this enzyme to help maintain an erection after arousal. However, it doesn't work unless sexual arousal is achieved.

How much and how often should I take Cialis (Tadalafil)?

Take Cialis (Tadalafil) on a daily or as-needed basis, according to what your doctor prescribes. Your doctor takes your specific needs into account and guides you on how and when to take your prescribed dosage.

Commonly prescribed doses:

  • Cialis (Tadalafil) is taken as needed, with 10mg as a single dose. Take it 30 minutes before sexual activity. Only take Cialis (Tadalafil) once a day.
  • Take 2.5mg of Cialis (Tadalafil) once a day, at the same time every day.

Ask your doctor to adjust your dose as needed. This may mean increasing your dose to 20mg or decreasing it to 5mg.

Which drug interactions do I need to keep an eye out for when taking Cialis (Tadalafil)?

Some drug combinations are safe to take together. However, it's important to check with your doctor about any possible drug interactions before taking Cialis (Tadalafil). Don't take Cialis (Tadalafil) before checking your current medications with your doctor.

Below are medications that may interact with Cialis (Tadalafil):

  • Alpha-Agonists: Clonidine, Methyldopa
  • Alpha-Blockers: Alfuzosin, Doxazosin, Tamsulosin, or Terazosin
  • Some Antibiotics: Clarithromycin, Erythromycin, Metronidazole, Norfloxacin, Rifabutin, Rifampin, or Tetracycline
  • Antidepressants: Desipramine or Sertraline
  • Antifungal Medications: Itraconazole, Ketoconazole, or Voriconazole
  • Cystic Fibrosis Medications: Ivacaftor
  • Epilepsy Medications: Carbamazepine, Oxcarbazepine, Phenobarbital, Phenytoin, or Primidone
  • Erectile Dysfunction Medications: Alprostadil, Sildenafil, Vardenafil
  • Heart Medications: Amlodipine, Amiodarone, Atenolol, Candesartan, Captopril, Clonidine, Diltiazem, Enalapril, Irbesartan, losartan, Nifedipine, Propranolol, Sotalol, or Verapamil
  • Hepatitis Medications: Boceprevir and Simeprevir
  • HIV Medications: Atazanavir, Delavirdine, Efavirenz, Indinavir, Etravirine, Ritonavir, Nevirapine, Saquinavir, or Tipranavir)
  • Nitrates: Amyl Nitrate, Isosorbide Dinitrate, Isosorbide Mononitrate, or Nitroglycerin
  • Others: Aprepitant, Cyclosporine, or Imatinib

Did you know that Tadalafil is the same as Cialis - except much more cost-effective?

The generic version of Cialis is called Tadalafil. The FDA has strict guidelines that ensure that generic drugs contain the same active ingredients. This makes sure that generics are just as effective as their brand name versions.

Pricing however, is substantially different between the two. Tadalafil costs on average 50% LESS than Cialis!

This is because Tadalafil is produced by many manufacturers who are free to set their own competitive pricing. As opposed to Cialis, which is only manufactured by Eli Lilly. Eli Lilly is then free to charge a "premium" price for their brand name medication.

So if you're interested in Cialis as a treatment, we highly suggest purchasing Tadalafil. It's the same exact drug but significantly cheaper!

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